Development of trimester-specific reference intervals for thyroid hormones based on real-world data using a maximum likelihood method
Trimester-specific reference intervals of TSH and FT4 for pregnancies were established using the maximum likelihood method. Compared with guideline-suggested reference intervals, no clinically significant discrepancies in FT4 and narrower limits in TSH were observed.
Authors
- Xiangrong Yang (ORCID: https://orcid.org/0000-0002-7230-4535)
- Zhao‐Xi Wang
- Yang Zou (ORCID: https://orcid.org/0009-0009-4221-5820)
- Xiaoyan Chen (ORCID: https://orcid.org/0000-0003-4583-7712)
- Yuqiang Huang (ORCID: https://orcid.org/0000-0003-3290-8243)
- Zhaoqi Gu
- Yunxia Chu
Institutions
- Shanghai International Studies University (CN)
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Linyi People's Hospital (CN)
- Linyi City Chinese Medicine Hospital (CN)
- Shandong Maternal and Child Health Hospital (CN)
Publication Details
- Journal
- Laboratory Medicine
- Published
- 2025-08-17
- DOI
- https://doi.org/10.1093/labmed/lmaf053
- Primary Topic
- Thyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00