Therapeutic potential of AAV8-mediated IL-17RA extracellular domain gene delivery in an imiquimod-induced mouse model of psoriasis.
AAV8-mediated IL-17RA(ECD) gene delivery effectively blocks cutaneous inflammation and attenuates inflammatory cytokines overexpression in an IMQ-induced mouse model of psoriasis, highlighting its therapeutic potential for chronic inflammatory skin diseases.
Authors
- Chunyu Cao (ORCID: https://orcid.org/0000-0003-3043-5673)
- Huibin Xie
- Yafeng Lv (ORCID: https://orcid.org/0000-0003-1873-593X)
- Danping Li (ORCID: https://orcid.org/0000-0002-5211-8559)
- Yu Cao (ORCID: https://orcid.org/0000-0001-6968-1180)
- Hongyan Wu
Institutions
- China Three Gorges University (CN)
- Second Hospital of Yichang (CN)
Publication Details
- Journal
- Molecular Immunology
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1016/j.molimm.2025.11.001
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00