Genetically Determined Alterations in Inflammation and Infection-Associated Genes are Associated With Hydrocephalus in Patients of African Ancestry

We identified genetically determined alterations in inflammation and infection-associated genes underlying HC in patients of mixed African ancestry in the US. Coevolution of humans and pathogen-imposed selection pressures have likely differentially shaped the genetic etiology of HC across populations, but large-scale human genetics studies, experimental validation, and replication in African ancestry cohorts are needed.