Integrative evidence for causal links between gut microbiota and Schizophrenia: A Mendelian randomization and 16S rRNA study
By integrating MR with 16S rRNA V3-V4 sequencing, this study provides convergent evidence for a potential causal role of specific gut microbial taxa, particularly <i>Bifidobacterium</i>, in contributing to schizophrenia risk. Our findings underscore the context-dependent nature of host-microbiota interactions and support the need for strain-level and functional studies to further elucidate schizophrenia pathogenesis.
Authors
- An‐Qi Chen (ORCID: https://orcid.org/0000-0001-9857-0594)
- Jianye Zeng
- Chengtao Li (ORCID: https://orcid.org/0000-0001-6852-9144)
- Suhua Zhang (ORCID: https://orcid.org/0000-0002-3984-9728)
- Chun Yang (ORCID: https://orcid.org/0000-0002-6293-9158)
- Shilin Li (ORCID: https://orcid.org/0000-0002-2371-938X)
- Ping Huang (ORCID: https://orcid.org/0000-0002-6333-8338)
- Yingnan Bian (ORCID: https://orcid.org/0000-0002-8651-8737)
- Xiumei Zhu
- Huajie Ba
Institutions
- Second Military Medical University (CN)
- Fudan University (CN)
- Shanghai Public Security Bureau (CN)
- Institute of Forensic Science (CN)
- Shanghai Pudong New Area Gongli Hospital (CN)
- Chinese People's Liberation Army (CN)
- China Medical University (CN)
Publication Details
- Journal
- Brain Behavior & Immunity - Health
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1016/j.bbih.2025.101123
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00