Dermatological implications of alignment-based de-hosting and bioinformatics pipelines on shotgun microbiome analysis
Our findings underscore the decisive impact of bioinformatic pipeline selection on skin microbiome analysis and offer actionable guidance for reproducible and clinically meaningful research. We present a customizable workflow that enhances reproducibility and transparency while improving the translational value of metagenomic data. This approach strengthens the reliability of microbiome studies and supports the development of precision diagnostics and personalized therapeutic strategies in dermatology.
Authors
- Vivian Labovsky
- Elmer A. Fernández (ORCID: https://orcid.org/0000-0002-4711-8634)
- Montserrat Rivero (ORCID: https://orcid.org/0000-0002-5834-1559)
- Leonardo Néstor Rubén Dandeu
- Daniela Orschanski
Institutions
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Universidad Nacional de Córdoba (AR)
- Centro Científico Tecnológico - Córdoba (AR)
- Instituto de Neurología de Buenos Aires (AR)
- Instituto Cardiovascular de Buenos Aires (AR)
- Universidad Argentina de la Empresa (AR)
- Experimental Medicine and Biology Institute (AR)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1186/s12967-025-07246-z
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Consejo Nacional de Investigaciones Científicas y Técnicas