Genetically predicted <scp>KIR2DS4</scp> mediate the association between gut microbe <scp>K10</scp> and osteoporosis fractures: A mediation Mendelian randomization study

This study provides compelling evidence supporting the causal involvement of specific gut microbiota and proteins in susceptibility to osteoporosis fractures. The identification of KIR2DS4 as a mediator in the K10-osteoporosis fractures relationship highlights a potential therapeutic target for osteoporosis management. These findings have significant implications for our understanding of the pathogenesis of osteoporosis, underscoring the importance of gut microbiota and protein metabolism in disease susceptibility.