Directly reprogrammed NK cells driven by BCL11B depletion enhance targeted immunotherapy against pancreatic ductal adenocarcinoma
This study presents a synergistic immunotherapy platform that integrates NK reprogramming, CAR engineering, and tumor sensitization. The combinatorial approach significantly enhances antitumor efficacy in PDAC and offers a promising strategy for overcoming immune resistance in solid tumors.
Authors
- Binna Seol
- Ji Eun Choi (ORCID: https://orcid.org/0000-0001-9132-2029)
- Ji Young Lee (ORCID: https://orcid.org/0000-0002-3279-7865)
- Yee Sook Cho
- Han‐Seop Kim (ORCID: https://orcid.org/0000-0002-6400-8306)
- Jae Yun Kim (ORCID: https://orcid.org/0000-0002-1230-5712)
Institutions
- Korea Research Institute of Bioscience and Biotechnology (KR)
- Korea University of Science and Technology (KR)
Publication Details
- Journal
- Journal of Hematology & Oncology
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1186/s13045-025-01730-1
- Citations
- 3
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- National Research Foundation
- Korea Research Institute of Bioscience and Biotechnology
- National Research Foundation of Korea