Acute ataxia in children: etiological spectrum and clinical characteristics
The etiology of acute ataxia in children varies significantly by age, necessitating tailored diagnostic approaches. For cases suggestive of central nervous system demyelination or recurrent ataxia, comprehensive evaluations, including autoantibody testing, tumor screening, and genetic/metabolic assessments, should be considered to guide management and improve outcomes. CSF OCB positivity may identify an APCA subgroup with more pronounced inflammatory features and a potentially higher relapse risk.
Authors
- Suzhen Sun (ORCID: https://orcid.org/0000-0001-8075-9137)
- Chao Gao (ORCID: https://orcid.org/0000-0001-6652-5457)
- Chong Liu (ORCID: https://orcid.org/0000-0001-6425-2045)
- Lihui Wang (ORCID: https://orcid.org/0000-0001-8960-8642)
- Baoguang Li (ORCID: https://orcid.org/0000-0002-5546-8319)
- Qing Zhao (ORCID: https://orcid.org/0009-0007-2536-5080)
Institutions
- Hebei Medical University (CN)
- Hospital of Hebei Province (CN)
- First Affiliated Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Frontiers in Pediatrics
- Published
- 2025-11-13
- DOI
- https://doi.org/10.3389/fped.2025.1613558
- Primary Topic
- Autoimmune Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00