Case Report: Conservative management of hemophagocytic lymphohistiocytosis with fulminant hepatic failure in a pediatric leukemia patient

This case highlights the diagnostic challenges of HLH in immunocompromised children, where early signs such as fever and cytopenias may be misattributed to sepsis or chemotherapy-related complications. It underscores the importance of including HLH in the differential diagnosis of ALF in high-risk patients and demonstrates that prompt recognition and targeted treatment of the hyperinflammatory state can be lifesaving, even in severe presentations.

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Publication Details

Journal
Frontiers in Pediatrics
Published
2025-11-13
DOI
https://doi.org/10.3389/fped.2025.1719708
Citations
1
Primary Topic
Autoimmune and Inflammatory Disorders Research
Type
article
Field-Weighted Citation Impact
1.77
Controls
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article

Case Report: Conservative management of hemophagocytic lymphohistiocytosis with fulminant hepatic failure in a pediatric leukemia patient

Catarina Amorim, Susana Santos, Carlos Escobar, Filipa Paixão et al.
1 citations
Frontiers in Pediatrics
Autoimmune and Inflammatory Disorders Research
1.77
article

Case Report: Conservative management of hemophagocytic lymphohistiocytosis with fulminant hepatic failure in a pediatric leukemia patient

Catarina Amorim, Susana Santos, Carlos Escobar, Filipa Paixão, André Salvada
article en
1 citations

Abstract

This case highlights the diagnostic challenges of HLH in immunocompromised children, where early signs such as fever and cytopenias may be misattributed to sepsis or chemotherapy-related complications. It underscores the importance of including HLH in the differential diagnosis of ALF in high-risk patients and demonstrates that prompt recognition and targeted treatment of the hyperinflammatory state can be lifesaving, even in severe presentations.

Frontiers in PediatricsVol. 13
Hospital Prof. Dr. Fernando Fonseca (PT), Instituto Português de Oncologia Francisco Gentil (PT)
Openalex Percentile: Top 11%
Autoimmune and Inflammatory Disorders Research
1.77
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Case Report: Conservative management of hemophagocytic lymphohistiocytosis with fulminant hepatic failure in a pediatric leukemia patient — Catarina Amorim, Susana Santos, et al. · Frontiers in Pediatrics (2025) | TGRS Research Map | TGRS