Case Report: Conservative management of hemophagocytic lymphohistiocytosis with fulminant hepatic failure in a pediatric leukemia patient
This case highlights the diagnostic challenges of HLH in immunocompromised children, where early signs such as fever and cytopenias may be misattributed to sepsis or chemotherapy-related complications. It underscores the importance of including HLH in the differential diagnosis of ALF in high-risk patients and demonstrates that prompt recognition and targeted treatment of the hyperinflammatory state can be lifesaving, even in severe presentations.
Authors
- Catarina Amorim (ORCID: https://orcid.org/0000-0002-9538-2333)
- Susana Santos (ORCID: https://orcid.org/0000-0003-0613-3181)
- Carlos Escobar (ORCID: https://orcid.org/0009-0003-7350-3098)
- Filipa Paixão
- André Salvada
Institutions
- Hospital Prof. Dr. Fernando Fonseca (PT)
- Instituto Português de Oncologia Francisco Gentil (PT)
Publication Details
- Journal
- Frontiers in Pediatrics
- Published
- 2025-11-13
- DOI
- https://doi.org/10.3389/fped.2025.1719708
- Citations
- 1
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 1.77