Cold temperature enhances innate eosinophilic airway inflammation via transient receptor potential ankyrin1
These findings suggest that TRPA1 channels expressed in airway epithelial cells play a critical role in producing TSLP, contributing to the enhancement of eosinophilic airway inflammation mediated by innate immunity upon cold air exposure, providing valuable insights into the mechanisms underlying asthma exacerbation triggered by cold temperatures.
Authors
- Hiroshi Inoue (ORCID: https://orcid.org/0000-0002-9969-2152)
- Keiko Mizuno (ORCID: https://orcid.org/0000-0001-6738-7906)
- Takahiro Matsuyama (ORCID: https://orcid.org/0009-0009-5167-8579)
- Koichi Takagi (ORCID: https://orcid.org/0009-0009-7927-3688)
- Hiromi Matsuyama
- Kentaro Tanaka (ORCID: https://orcid.org/0000-0001-8219-4731)
- Keiko Kan‐o (ORCID: https://orcid.org/0000-0002-7736-588X)
- Kentaro Machida (ORCID: https://orcid.org/0000-0002-9394-091X)
- Yoichi Dotake
- T Kuwaki
Institutions
- Kagoshima University (JP)
- Kyushu University (JP)
- Tokyo Women's Medical University (JP)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-13
- DOI
- https://doi.org/10.3389/fimmu.2025.1655919
- Citations
- 1
- Primary Topic
- Ion Channels and Receptors
- Type
- article
- Field-Weighted Citation Impact
- 1.46