Sars-Cov-2 spike protein and plasma from COVID-19 patients induce extracellular traps by myeloid-derived suppressor cells
These findings highlight a previously unrecognized contribution of PMN-MDSCs to the thrombotic complications in severe COVID-19 cases, underscoring their detrimental impact on disease progression.
Authors
- Zulema Percario (ORCID: https://orcid.org/0000-0003-1474-6682)
- Germana Grassi (ORCID: https://orcid.org/0000-0001-8168-8721)
- Stefania Notari
- Roberta Nardacci (ORCID: https://orcid.org/0000-0002-9209-1207)
- Chiara Agrati
- Simona Gili
- Alessandra Sacchi (ORCID: https://orcid.org/0000-0003-4964-386X)
- Elisabetta Affabris (ORCID: https://orcid.org/0000-0001-5142-8144)
- Harpreet Kaur Lamsira
- Rita Casetti (ORCID: https://orcid.org/0000-0002-7574-8780)
- Paola Vacca (ORCID: https://orcid.org/0000-0002-0757-0108)
- Luisa Marchioni
- Flavia Cristofanelli
- Dorotea Rubino
- Eleonora Cimini (ORCID: https://orcid.org/0000-0002-2659-0868)
- Veronica Bordoni (ORCID: https://orcid.org/0000-0002-1747-2245)
- Nicola Tumino (ORCID: https://orcid.org/0000-0003-3773-8829)
- Francesca Nonini
Institutions
- Roma Tre University (IT)
- Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani (IT)
- Saint Camillus International University of Health and Medical Sciences (IT)
- Bambino Gesù Children's Hospital (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-11-13
- DOI
- https://doi.org/10.3389/fcimb.2025.1612198
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero della Salute
- Ministero dell'Università e della Ricerca