Glymphatic system impairment in cerebral small vessel disease: associations with perivascular space volume and cognition
Our findings demonstrate that impaired glymphatic function was associated with enlarged BG-PVS, especially in the putamen, and worse cognitive performance, highlighting its potential role in disease progression and cognitive decline in CSVD.
Authors
- Suhuan Chen (ORCID: https://orcid.org/0009-0004-1324-5426)
- Lulu Ai
- Zhiwei Li (ORCID: https://orcid.org/0000-0003-4575-5258)
- Xiaoqun Zhu (ORCID: https://orcid.org/0000-0001-9042-0057)
- Huipeng Huang
- Zhongwu Sun (ORCID: https://orcid.org/0000-0002-7230-9328)
- Chaojuan Huang (ORCID: https://orcid.org/0000-0003-1026-5400)
- Xia Zhou (ORCID: https://orcid.org/0000-0002-4037-6809)
Institutions
- Sun Yat-sen University (CN)
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-11-13
- DOI
- https://doi.org/10.3389/fnagi.2025.1680094
- Citations
- 4
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 3.64
Funders
- National Natural Science Foundation of China
- Anhui University
- Natural Science Foundation of Anhui Province