Excitatory-inhibitory imbalance in temporal lobe epilepsy: a 5T multimodal MRI biomarker for focus localization and drug resistance stratification
Multimodal 5T MRI integrating GluCEST and GABA-MRS provides a clinically feasible tool for lateralizing epileptogenic foci and stratifying drug resistance in TLE. The observed excitatory-inhibitory imbalance dynamics suggest distinct neurometabolic profiles underlying DR and DRES, advancing personalized therapeutic strategies.
Authors
- Xiaona Xia (ORCID: https://orcid.org/0000-0001-5438-2735)
- Lu Shi (ORCID: https://orcid.org/0000-0002-2114-6389)
- Xiangshui Meng (ORCID: https://orcid.org/0000-0001-5009-4218)
- Zhaodi Huang (ORCID: https://orcid.org/0009-0008-2316-0839)
- Qingjun Jiang (ORCID: https://orcid.org/0000-0002-3114-6905)
- Ke Xue (ORCID: https://orcid.org/0000-0002-9737-4636)
- Ying Xu (ORCID: https://orcid.org/0000-0002-4516-5314)
- Ying Wei (ORCID: https://orcid.org/0000-0001-9671-913X)
- Ling Li (ORCID: https://orcid.org/0000-0003-4498-9466)
- He Deng
Institutions
- Qingdao University (CN)
- Fujian Medical University (CN)
- Shandong University (CN)
- Mengchao Hepatobiliary Hospital (CN)
- United Imaging Healthcare (China) (CN)
- Qingdao Center of Resource Chemistry and New Materials (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-11-13
- DOI
- https://doi.org/10.3389/fnagi.2025.1660608
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Qingdao Key Health Discipline Development Fund