Transcriptomic and Proteomic Profiling Shows Dysregulated Immune and Metabolic Pathways in Arrhythmogenic Cardiomyopathy
This integrated transcriptomic and proteomic study of myocardial tissue and plasma from patients with ACM compared with those with DCM and healthy controls, identified key dysregulated pathways, involving immune response, inflammation and oxidative and mitochondrial stress. Desmoyokin and OCIAD1, in particular, may represent specific candidate biomarkers for ACM.
Authors
- Frank Thomas Ruschitzka (ORCID: https://orcid.org/0000-0001-5972-0596)
- Ardan M. Saguner (ORCID: https://orcid.org/0000-0003-1896-0803)
- Paolo Nanni (ORCID: https://orcid.org/0000-0001-8429-3557)
- Fırat Duru (ORCID: https://orcid.org/0000-0002-4748-0158)
- Hendrik Milting (ORCID: https://orcid.org/0000-0001-9722-0007)
- Lukas Weidmann (ORCID: https://orcid.org/0009-0001-4948-0995)
- Peter K. Bode (ORCID: https://orcid.org/0000-0002-9633-4042)
- Corinna Brunckhorst
- Felix Christoph Tanner (ORCID: https://orcid.org/0000-0002-4315-2667)
- Deniz Akdiş
- Liang Chen (ORCID: https://orcid.org/0000-0001-6374-112X)
- Anna Gaertner
Institutions
- University of Zurich (CH)
- Heart and Diabetes Center North Rhine-Westphalia (DE)
- ETH Zurich (CH)
- Kantonsspital Winterthur (CH)
- University Hospital of Zurich (CH)
- Center for Translational Molecular Medicine (NL)
Publication Details
- Journal
- ESC Heart Failure
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1002/ehf2.70013
- Citations
- 1
- Primary Topic
- Cardiovascular Effects of Exercise
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Schweizerische Herzstiftung
- Baugarten Stiftung