Case Report: A rare case of mixed medullary-papillary thyroid carcinoma with mixed lymph node metastasis

The peculiarity of this case lies in the fact that preoperative serological tests showed abnormally elevated levels of CT, CEA and TG. FNAC of the right lobe of the thyroid indicated MTC, but at the same time, the puncture of cervical lymph nodes revealed the presence of PTC components. In such a situation, the possibility of coexistence of MTC and PTC should be highly suspected. A standardized surgical treatment plan should be selected, and during the pathological examination, standardized sampling and meticulous reading of the slides should be emphasized, combined with immunohistochemical detection, to reduce the risk of missed diagnosis, provide accurate pathological diagnosis, and thereby offer reliable basis for the formulation of postoperative treatment strategies and prognosis assessment.

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Publication Details

Journal
Frontiers in Oncology
Published
2025-11-13
DOI
https://doi.org/10.3389/fonc.2025.1676422
Primary Topic
Thyroid Cancer Diagnosis and Treatment
Type
article
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article

Case Report: A rare case of mixed medullary-papillary thyroid carcinoma with mixed lymph node metastasis

De-shi Yang, Jing He
Frontiers in Oncology
Thyroid Cancer Diagnosis and Treatment
article

Case Report: A rare case of mixed medullary-papillary thyroid carcinoma with mixed lymph node metastasis

De-shi Yang, Jing He
article en

Abstract

The peculiarity of this case lies in the fact that preoperative serological tests showed abnormally elevated levels of CT, CEA and TG. FNAC of the right lobe of the thyroid indicated MTC, but at the same time, the puncture of cervical lymph nodes revealed the presence of PTC components. In such a situation, the possibility of coexistence of MTC and PTC should be highly suspected. A standardized surgical treatment plan should be selected, and during the pathological examination, standardized sampling and meticulous reading of the slides should be emphasized, combined with immunohistochemical detection, to reduce the risk of missed diagnosis, provide accurate pathological diagnosis, and thereby offer reliable basis for the formulation of postoperative treatment strategies and prognosis assessment.

Frontiers in OncologyVol. 15
Mianyang Third People's Hospital (CN), Sichuan Mianyang 404 Hospital (CN)
Openalex Percentile: Top 54%
Thyroid Cancer Diagnosis and Treatment
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