<scp>VEGFA</scp> ‐centric angiogenic genetic variants drive hypertension and dyslipidaemia susceptibility in type 2 diabetes mellitus: A multilocus synergistic cohort study
These findings underscored VEGFA rs3025020 as a genetic hub coordinating multilocus angiogenic dysregulation, driving HTN and DYS pathogenesis in T2DM. Our results highlight the potential for genotype-guided anti-angiogenic therapies to mitigate metabolic-vascular deterioration in high-risk diabetic populations.
Authors
- Hailian Chen
- Mengna Guo (ORCID: https://orcid.org/0000-0003-1480-0474)
- Chao Zuo (ORCID: https://orcid.org/0000-0002-1461-0032)
- Yi Liu (ORCID: https://orcid.org/0009-0007-5858-9056)
- Dongli Yang (ORCID: https://orcid.org/0000-0001-5026-3149)
- Jing Cheng (ORCID: https://orcid.org/0000-0002-5379-2203)
- Ziqiang Wang (ORCID: https://orcid.org/0000-0002-4676-3447)
- Zhuo Yang (ORCID: https://orcid.org/0000-0002-5296-8596)
- Xiang Lu (ORCID: https://orcid.org/0000-0003-0647-9123)
- Yongchao Qiao (ORCID: https://orcid.org/0000-0002-2902-9566)
- Yu Wang (ORCID: https://orcid.org/0000-0002-8833-9564)
Institutions
- Bengbu Medical College (CN)
- Guilin Medical University (CN)
Publication Details
- Journal
- Diabetic Medicine
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1111/dme.70169
- Primary Topic
- Angiogenesis and VEGF in Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00