Epigenetic regulation of TIPE3 in nasopharyngeal carcinoma and its impact on the hedgehog signaling pathway
The study reveals that TIPE3 is epigenetically regulated by enhancer elements, which are modulated by KAT2A and SETD7, and that TIPE3 promotes NPC progression through activation of the Hedgehog signaling pathway. These findings suggest that targeting the enhancer-mediated regulation of TIPE3 and the associated signaling pathways could offer new therapeutic strategies for NPC.
Authors
- Zhongqiang Cheng
- Yanxun Guo (ORCID: https://orcid.org/0000-0001-7927-8280)
- Zhijie Fang
- Kong Yue (ORCID: https://orcid.org/0000-0002-3039-638X)
- Lifeng Huang (ORCID: https://orcid.org/0009-0004-2064-218X)
- Yanshu Zhang
Institutions
- Xuzhou Medical College (CN)
- Nantong University (CN)
- Suzhou Municipal Hospital (CN)
- Yancheng First People's Hospital (CN)
- First Affiliated Hospital of Bengbu Medical College (CN)
- Lu'an First People's Hospital (CN)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1007/s00018-025-05924-1
- Primary Topic
- Hedgehog Signaling Pathway Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00