Validation and refinement of the 8th edition of the AJCC staging system for esophageal squamous cell carcinoma treated with definitive IMRT or chemo-IMRT: a Chinese multi-institutional retrospective study
Combining T4a/T4b and SLN subclassification enhanced prognostic precision in ESCC, with the autoRPA staging demonstrating superior hazard consistency, sample balance, and predictive accuracy compared to the 8th edition AJCC staging, thereby guiding therapeutic strategies.
Authors
- Zefen Xiao (ORCID: https://orcid.org/0000-0003-0503-6814)
- Qifeng Wang (ORCID: https://orcid.org/0000-0002-3036-6084)
- Kuaile Zhao (ORCID: https://orcid.org/0000-0001-8663-2874)
- Jianchao Lu (ORCID: https://orcid.org/0000-0002-0006-7016)
- Xin Wang (ORCID: https://orcid.org/0000-0003-1753-2786)
- Yun Chen (ORCID: https://orcid.org/0000-0001-6917-7814)
- Jiao Li (ORCID: https://orcid.org/0000-0003-4691-3625)
- Wenbin Shen (ORCID: https://orcid.org/0009-0009-6659-0174)
- Jingyuan Wen (ORCID: https://orcid.org/0000-0001-7833-5546)
- Jie Li (ORCID: https://orcid.org/0000-0002-2540-7494)
- Junqiang Chen (ORCID: https://orcid.org/0000-0002-9516-0634)
- Yaqi Song (ORCID: https://orcid.org/0000-0001-8236-2643)
- Honglei Luo (ORCID: https://orcid.org/0000-0003-0551-0651)
- Lina Zhao (ORCID: https://orcid.org/0000-0002-0011-6471)
- Wencheng Zhang (ORCID: https://orcid.org/0000-0001-5433-5146)
- Yu Lin (ORCID: https://orcid.org/0000-0001-6445-6603)
- Long-Qi Chen (ORCID: https://orcid.org/0000-0003-0505-0560)
- Wenji Xue
- Fei Zheng
- Zhunhao Zheng
- Ming-Qiu Chen
- Yuanji Xu
Institutions
- Hebei Medical University (CN)
- Fujian Medical University (CN)
- Shanghai Medical College of Fudan University (CN)
- University of Electronic Science and Technology of China (CN)
- Xuzhou Medical College (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Sichuan University (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- National Cancer Center (US)
- West China Hospital of Sichuan University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Huaian First People’s Hospital (CN)
- Fourth Hospital of Hebei Medical University (CN)
- Sichuan Cancer Hospital (CN)
- Second People’s Hospital of Huai’an (CN)
- Fujian Provincial Cancer Hospital (CN)
- Xijing Hospital (CN)
- Nanjing Medical University (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Radiation Oncology
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1186/s13014-025-02758-w
- Primary Topic
- Esophageal Cancer Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China