Optogenetic Infection and Optical Stimulation: A Study on Auditory Responses in Guinea Pig Cochlear Neurons
This study demonstrates the viability of optogenetic activation of the auditory system in adult guinea pigs through the transduction of AAV-ChR2(H134R) in SGNs. Cochlear optogenetics demonstrates potential as a hearing restoration technology, providing a basis for further clinical research and opening new avenues for investigation.
Authors
- Ning Yu (ORCID: https://orcid.org/0000-0001-6596-9216)
- Chen Liu (ORCID: https://orcid.org/0000-0001-5204-8143)
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Chinese PLA General Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Beijing Children’s Hospital (CN)
Publication Details
- Journal
- Journal of Otology
- Published
- 2025-10-01
- DOI
- https://doi.org/10.26599/joto.2025.9540036
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China