SIRT3 knockout aggravates LPS-induced eustachian tube dysfunction
SIRT3-KO increased resistance to ET opening in mice exposed to LPS, and this effect may be related to the upregulated MUC5AC expression, the increased surface tension of the luminal fluid and the impaired MCC function in mice exposed to LPS.
Authors
- Hongjun Xiao (ORCID: https://orcid.org/0000-0002-1776-5435)
- Xiaohua Lian (ORCID: https://orcid.org/0000-0002-3682-2087)
- Wei Tang (ORCID: https://orcid.org/0000-0003-4722-6093)
- Shimin Zong (ORCID: https://orcid.org/0009-0004-3709-1599)
- Huimin Zhang (ORCID: https://orcid.org/0000-0002-4407-6723)
- Ting Li (ORCID: https://orcid.org/0000-0001-5145-3024)
- Tianyi Liu (ORCID: https://orcid.org/0000-0002-2624-7146)
- Xuan Yu (ORCID: https://orcid.org/0009-0009-9130-2939)
- Wenting Yu
Institutions
- Union Hospital (HK)
- Wuhan University (CN)
- Wuhan Prevention and Treatment Center for Occupational Diseases (CN)
- Renmin Hospital of Wuhan University (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Otology
- Published
- 2025-10-01
- DOI
- https://doi.org/10.26599/joto.2025.9540033
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Huazhong University of Science and Technology
- Tongji University
- National Key Research and Development Program of China
- Tongji Medical College, Huazhong University of Science and Technology