Thymosin β4 released by mast cells under stress conditions impairs intestinal epithelial barrier <i>via</i> IL22RA1/JAK1/STAT3 signaling in irritable bowel syndrome
Collectively, these results suggest that Tβ4, which is abundant in IBS mucus and the secretome of MCs, plays a crucial role in the pathogenesis of IBS <i>via</i> IL22RA1/JAK1/STAT3 signaling, with potential implications for diagnostic and therapeutic targeting.
Authors
- Qiong Wang (ORCID: https://orcid.org/0000-0002-6898-6879)
- Xiaoqin Bai
- Kaidi Sun (ORCID: https://orcid.org/0000-0003-3247-4043)
- Zhao-Yu Zeng
- Yuanyuan Chen (ORCID: https://orcid.org/0000-0002-5358-9213)
- Yueshan Sun
- Li Jiao (ORCID: https://orcid.org/0000-0002-0237-0262)
- Lei Liu (ORCID: https://orcid.org/0000-0002-4384-0005)
- Yuanbiao Guo (ORCID: https://orcid.org/0000-0002-7571-8864)
Institutions
- Third People's Hospital of Chengdu (CN)
Publication Details
- Journal
- World Journal of Gastroenterology
- Published
- 2025-11-13
- DOI
- https://doi.org/10.3748/wjg.v31.i42.111706
- Primary Topic
- Mast cells and histamine
- Type
- article
- Field-Weighted Citation Impact
- 0.00