N-Palmitoyl Glutamine Is a Candidate Mediator of Cardiorespiratory Fitness
We identified a novel, lipidated amino acid, N-pal-gln, that is positively associated with VO<sub>2</sub>max, increases after regular aerobic exercise, and is inversely associated with incident mortality. N-pal-gln stimulates mitochondrial biogenesis and efficiency, demonstrating its potential role as an exercise-stimulated transducer of cardiorespiratory fitness.
Authors
- Andrew Perry (ORCID: https://orcid.org/0000-0003-3342-6158)
- Jeremy Robbins (ORCID: https://orcid.org/0000-0002-9672-4841)
- Alexis C. Wood (ORCID: https://orcid.org/0000-0001-7616-2119)
- Jacob L. Barber (ORCID: https://orcid.org/0000-0002-8132-1601)
- Scott A. Summers (ORCID: https://orcid.org/0000-0002-4919-0592)
- Ravi V. Shah (ORCID: https://orcid.org/0000-0002-4471-7156)
- Prashant Rao (ORCID: https://orcid.org/0000-0002-5396-4677)
- Usman A. Tahir (ORCID: https://orcid.org/0000-0002-3657-6082)
- Kent D. Taylor (ORCID: https://orcid.org/0000-0002-2756-4370)
- Gregory D. Lewis (ORCID: https://orcid.org/0000-0001-8108-8240)
- Julián Ávila-Pacheco (ORCID: https://orcid.org/0000-0001-9388-3946)
- Matthew Nayor (ORCID: https://orcid.org/0000-0002-6993-9396)
- Mark D. Benson (ORCID: https://orcid.org/0000-0001-8977-2389)
- Jerome I. Rotter (ORCID: https://orcid.org/0000-0001-7191-1723)
- Shuliang Deng (ORCID: https://orcid.org/0000-0002-1543-2733)
- Laura M. Raffield (ORCID: https://orcid.org/0000-0002-7892-193X)
- Anthony R.P. Verkerke (ORCID: https://orcid.org/0000-0002-6198-4723)
- Wendy S. Post (ORCID: https://orcid.org/0000-0002-8655-5204)
- Robert E. Gerszten (ORCID: https://orcid.org/0000-0002-6767-7687)
- Clary B. Clish (ORCID: https://orcid.org/0000-0001-8259-9245)
- Mark A. Sarzynski (ORCID: https://orcid.org/0000-0001-6705-0668)
- Michael E. Hall (ORCID: https://orcid.org/0000-0002-5733-1025)
- Patricia E. Miller (ORCID: https://orcid.org/0000-0002-0141-717X)
- Gaurav Tiwari (ORCID: https://orcid.org/0009-0000-2540-6005)
- Claude Bouchard (ORCID: https://orcid.org/0000-0002-0048-491X)
- Stephen S. Rich (ORCID: https://orcid.org/0000-0003-3872-7793)
- Shingo Kajimura (ORCID: https://orcid.org/0000-0003-0672-5910)
- Xu Shi (ORCID: https://orcid.org/0000-0002-9473-0359)
- James G. Wilson (ORCID: https://orcid.org/0009-0002-0283-2970)
- Yuntian Guan (ORCID: https://orcid.org/0000-0003-0809-768X)
- Foje-Geh Tendoh (ORCID: https://orcid.org/0009-0001-7758-9445)
Institutions
- Pennington Biomedical Research Center (US)
- Broad Institute (US)
- Boston University (US)
- University of North Carolina at Chapel Hill (US)
- Beth Israel Deaconess Medical Center (US)
- Howard Hughes Medical Institute (US)
- Johns Hopkins University (US)
- University of South Carolina (US)
- University of Utah (US)
- Johns Hopkins Medicine (US)
- University of Mississippi Medical Center (US)
- Massachusetts General Hospital (US)
- Los Angeles Biomedical Research Institute (US)
- Children's Nutrition Research Center at Baylor College of Medicine (US)
- Department of Health Services (US)
- University of Virginia (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Circulation
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1161/circulationaha.125.074187
- Citations
- 5
- Primary Topic
- Cardiovascular and exercise physiology
- Type
- article
- Field-Weighted Citation Impact
- 11.91