LRRFIP1 Inhibits White Adipocyte Differentiation by Suppressing the E2F6/C/EBPα Axis
Our findings reveal that LRRFIP1 plays a crucial inhibitory role in WAD by negatively regulating the E2F6/C/EBPα axis. This discovery not only enriches our understanding of the molecular networks governing WAD but also holds great promise for creating targeted therapies for obesity and associated metabolic conditions.
Authors
- Dongmei Wang (ORCID: https://orcid.org/0000-0002-9922-5626)
- Yuwen Jiao (ORCID: https://orcid.org/0000-0001-9417-4279)
- Liming Tang (ORCID: https://orcid.org/0000-0002-3730-3131)
- Xiaoqiang Zhan
- Lei Zhou (ORCID: https://orcid.org/0000-0003-4605-500X)
- Jianyao Xue (ORCID: https://orcid.org/0000-0001-8302-9885)
Institutions
- Dalian Medical University (CN)
- Jiangsu Vocational College of Medicine (CN)
- Yancheng Third People's Hospital (CN)
- Changzhou No.2 People's Hospital (CN)
Publication Details
- Journal
- Diabetes & Metabolism Journal
- Published
- 2025-11-12
- DOI
- https://doi.org/10.4093/dmj.2025.0178
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province