An Extracellular Matrix–Producing Subset of Cancer-Associated Fibroblasts Drives Chemoresistance in Breast Cancer via SRC Activation and G0S2 Upregulation
Integration of patient data with ex vivo tumor-on-chip modeling identifies an extracellular matrix-producing myofibroblast population that contributes to chemoresistance and can be targeted to improve outcomes in triple-negative breast cancer.
Authors
- Stéphanie Descroix (ORCID: https://orcid.org/0000-0003-0027-352X)
- Rana Mhaidly (ORCID: https://orcid.org/0000-0003-2029-1215)
- Arianna Mencattini (ORCID: https://orcid.org/0000-0002-3753-0457)
- Isabella Hofer (ORCID: https://orcid.org/0000-0002-2959-6755)
- Paul Henri Cottu (ORCID: https://orcid.org/0000-0001-6434-3932)
- Anne Vincent‐Salomon (ORCID: https://orcid.org/0000-0001-5754-5771)
- Maud Kamal (ORCID: https://orcid.org/0000-0003-1466-0950)
- Yann Kieffer (ORCID: https://orcid.org/0000-0003-2722-3071)
- Eugenio Martinelli (ORCID: https://orcid.org/0000-0002-6673-2066)
- Christophe Le Tourneau (ORCID: https://orcid.org/0000-0001-9772-4686)
- Claire Bonneau (ORCID: https://orcid.org/0000-0001-6251-286X)
- Maria Carla Parrini (ORCID: https://orcid.org/0000-0002-7082-9792)
- Fatima Mechta‐Grigoriou (ORCID: https://orcid.org/0000-0002-3751-6989)
- Constance Lamy (ORCID: https://orcid.org/0000-0003-0311-8031)
- Hugo Croizer (ORCID: https://orcid.org/0009-0009-4817-9875)
Institutions
- University of Rome Tor Vergata (IT)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université de Versailles Saint-Quentin-en-Yvelines (FR)
- Université Paris Cité (FR)
- Université Paris Sciences et Lettres (FR)
- Université Paris-Saclay (FR)
- Institut Pierre-Gilles de Gennes pour la Microfluidique (FR)
- La Ligue Contre le Cancer (FR)
- Institut Curie (FR)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1158/0008-5472.can-25-0966
- Citations
- 3
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 3.14