Dynamic and Ongoing <i>De Novo</i> L1 Retrotransposition Contributes to Genome Plasticity and Intrapatient Heterogeneity in Ovarian Cancer
L1 retrotransposition is a dynamic process that continues at late stages of high-grade serous ovarian cancer and can substantially contribute to intrapatient tumor heterogeneity.
Authors
- Barun Pradhan (ORCID: https://orcid.org/0000-0001-6016-4443)
- Matías Marín Falco (ORCID: https://orcid.org/0000-0002-6813-0050)
- Yilin Li (ORCID: https://orcid.org/0009-0005-9422-1334)
- Kari Lavikka (ORCID: https://orcid.org/0000-0002-4163-4945)
- Sampsa Hautaniemi (ORCID: https://orcid.org/0000-0002-7749-2694)
- Giulia Micoli (ORCID: https://orcid.org/0009-0003-9541-8177)
- Geoffrey J. Faulkner (ORCID: https://orcid.org/0000-0001-5769-4494)
- Kaisa Huhtinen (ORCID: https://orcid.org/0000-0001-9685-5246)
- Johanna Hynninen (ORCID: https://orcid.org/0000-0002-0854-7225)
- Liisa Kauppi (ORCID: https://orcid.org/0000-0002-6759-8997)
- Giovanni Marchi (ORCID: https://orcid.org/0000-0001-9513-1123)
- Kaiyang Zhang (ORCID: https://orcid.org/0000-0002-0470-9581)
- Juan M. Botto (ORCID: https://orcid.org/0009-0007-8409-2203)
- Sanna Pikkusaari (ORCID: https://orcid.org/0000-0002-2966-0446)
- Kathleen H. Burns (ORCID: https://orcid.org/0000-0003-1620-3761)
- Jaana Oikkonen (ORCID: https://orcid.org/0000-0002-1063-2736)
- Anna Vähärautio (ORCID: https://orcid.org/0000-0003-4721-3954)
- Richard M. Badge (ORCID: https://orcid.org/0000-0003-3201-336X)
- Sakari Hietanen (ORCID: https://orcid.org/0000-0003-4734-4743)
- Thomas R. Pisanic (ORCID: https://orcid.org/0000-0001-5796-0836)
- Fatih Genç (ORCID: https://orcid.org/0000-0001-5723-579X)
- Taru Muranen (ORCID: https://orcid.org/0000-0002-5895-1808)
- Minna Eriksson (ORCID: https://orcid.org/0009-0001-4168-9911)
- Sudhir Sundaresan (ORCID: https://orcid.org/0009-0000-6984-1332)
Institutions
- Boston Medical Center (US)
- University of Helsinki (FI)
- Johns Hopkins University (US)
- University of Leicester (GB)
- University of Turku (FI)
- The University of Queensland (AU)
- Helsinki University Hospital (FI)
- Turku University Hospital (FI)
- Mater Research (AU)
- Dana-Farber Cancer Institute (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
- Hospital District of Helsinki and Uusimaa (FI)
- University of Baltimore (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1158/0008-5472.can-24-4419
- Primary Topic
- Chromosomal and Genetic Variations
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission