IgM Anti-Ganglioside Binding and Complement Activation in an iPSC-Derived Motor Neuron Model for Multifocal Motor Neuropathy
This study demonstrates that IgM antibodies in serum samples from patients with MMN induce complement activation on iPSC MNs, which correlates significantly with clinical outcomes. In addition, our findings indicate that complement inhibitors offer a potentially targeted novel therapeutic strategy for MMN and that our iPSC MN model is a viable preclinical screening platform.
Authors
- Ruth Huizinga (ORCID: https://orcid.org/0000-0002-9563-4860)
- Elisabeth de Zeeuw (ORCID: https://orcid.org/0009-0005-8665-8747)
- W. Ludo van der Pol (ORCID: https://orcid.org/0000-0002-8970-2740)
- Jeanette H.W. Leusen (ORCID: https://orcid.org/0000-0003-4982-6914)
- Kevin Budding (ORCID: https://orcid.org/0000-0002-3827-7131)
- Ruben P. A. van Eijk (ORCID: https://orcid.org/0000-0002-7132-5967)
- Kim Dijkxhoorn (ORCID: https://orcid.org/0009-0005-9692-9360)
- Inge Van de Walle (ORCID: https://orcid.org/0000-0002-7631-399X)
- R. Jeroen Pasterkamp (ORCID: https://orcid.org/0000-0003-1631-6440)
- Lauri M. Bloemenkamp
- Daniëlle Krijgsman (ORCID: https://orcid.org/0000-0001-6101-7146)
- C. Erik Hack
- Jeroen W. Bos (ORCID: https://orcid.org/0000-0002-6230-1533)
- Bart C. Jacobs (ORCID: https://orcid.org/0000-0002-8985-2458)
Institutions
- Erasmus MC (NL)
- University Medical Center Utrecht (NL)
- Center for Translational Molecular Medicine (NL)
- Argenx (Belgium) (BE)
- Hersenstichting (NL)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1212/nxi.0000000000200482
- Primary Topic
- Peripheral Neuropathies and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00