Effectiveness of Cognitive Stimulation Therapy and structured Physical Activity Program in improving cognitive functions and enhancing the quality of life of Alzheimer’s patients: a three-arm randomized controlled trial

As the prevalence of Alzheimer's disease, a progressive neurodegenerative disorder characterized by cognitive decline and memory impairment, continues to increase, there is an urgent need for effective interventions that address cognitive impairment and improve individuals' overall quality of life. Cognitive Stimulation Therapy (CST) and physical activity have emerged as promising nonpharmacological approaches to address cognitive decline in patients with Alzheimer's disease. This study aimed to investigate the effects of Cognitive Stimulation Therapy and Physical Activity Programs on cognitive functions and quality of life in Alzheimer's patients. The sample of the study consisted of 75 individuals in total, 25 each in the Cognitive Stimulation Therapy, Physical Activity and Control groups. The results showed significant improvements in cognitive function in the Cognitive Stimulation Therapy group compared to the other groups, and in quality of life in both the Cognitive Stimulation Therapy and Physical Activity groups compared to the control group. Notably, the greatest improvement in quality of life was observed in the Cognitive Stimulation Therapy and Physical Activity group, highlighting the potential synergistic effects of combining these interventions. These findings underscore the importance of incorporating Cognitive Stimulation Therapy and Physical Activity Programs into the care regimen for elderly individuals with Alzheimer's disease to promote cognitive health and overall well-being. ClinicalTrials.gov Identifier number is NCT4378926.