Levosimendan versus dobutamine in acute decompensated heart failure: systematic review and meta-analysis of randomised controlled trials

Levosimendan reduced short-term mortality and hospital stay compared with dobutamine in patients with ADHF, although the certainty of evidence was moderate for mortality and very low for hospital stay. Larger trials are needed to confirm these findings.

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Publication Details

Journal
Heart
Published
2025-11-12
DOI
https://doi.org/10.1136/heartjnl-2025-326744
Primary Topic
Heart Failure Treatment and Management
Type
article
Field-Weighted Citation Impact
0.00
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article

Levosimendan versus dobutamine in acute decompensated heart failure: systematic review and meta-analysis of randomised controlled trials

Hugo Parente, Carlos Magliano, Matheus Fernandes de Oliveira, João Vitor Fazzio de Andrade Cordeiro et al.
Heart
Heart Failure Treatment and Management
article

Levosimendan versus dobutamine in acute decompensated heart failure: systematic review and meta-analysis of randomised controlled trials

Hugo Parente, Carlos Magliano, Matheus Fernandes de Oliveira, João Vitor Fazzio de Andrade Cordeiro, Diamantino Salgado, Laura Moita Sforza
article en

Abstract

Levosimendan reduced short-term mortality and hospital stay compared with dobutamine in patients with ADHF, although the certainty of evidence was moderate for mortality and very low for hospital stay. Larger trials are needed to confirm these findings.

Heart
Universidade Federal do Rio de Janeiro (BR), D’Or Institute for Research and Education (BR), Instituto Nacional de Cardiologia (BR)
Openalex Percentile: Top 49%
Heart Failure Treatment and Management
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