Association between non-invasive biomarkers and quality of life in Primary Sclerosing Cholangitis
QoL in PSC was associated with biomarkers of parenchymal liver fibrosis (LS, cT1), biliary disease (dominant strictures, RSIBD), and composite scores of disease severity (AOM). Increasing LS predicted further declines in QoL. Further research should explore MRCP+ metrics and their impact on QoL.
Authors
- Michael Pavlides (ORCID: https://orcid.org/0000-0001-9882-8874)
- Emma Louise Culver (ORCID: https://orcid.org/0000-0001-9644-8392)
- Adam Bailey (ORCID: https://orcid.org/0000-0002-8371-2147)
- Michael Brady (ORCID: https://orcid.org/0000-0002-2377-387X)
- Emmanuel Selvaraj
- José Leal (ORCID: https://orcid.org/0000-0001-7870-6730)
- Jingyu Dai (ORCID: https://orcid.org/0000-0002-0236-1534)
Institutions
- Warwick Hospital (GB)
- National Institute for Health and Care Research (GB)
- University of Oxford (GB)
- Oxford BioMedica (United Kingdom) (GB)
- South Warwickshire NHS Foundation Trust (GB)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1371/journal.pone.0335642
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 0.00