PIM1 induces hypoxia-related fibroblast senescence in a mouse model of stress urinary incontinence
This study identifies PIM1 as a critical mediator linking hypoxia-induced cellular senescence to the development of SUI. The PIM1 inhibitor AZD-1208 demonstrates promising therapeutic effects, offering a novel approach for the treatment of SUI, with particular relevance for postpartum prevention. These findings elucidate a comprehensive hypoxia-PIM1-senescence pathogenic pathway and identify a potential target for clinical intervention.
Authors
- Fangyi Zhu
- Lingyun Li (ORCID: https://orcid.org/0009-0001-9089-4073)
- Bingshu Li (ORCID: https://orcid.org/0000-0001-8276-0449)
- Hong Li (ORCID: https://orcid.org/0000-0002-3841-5557)
- Ya Xiao (ORCID: https://orcid.org/0000-0002-9673-883X)
- Liying Chen (ORCID: https://orcid.org/0000-0002-8895-3775)
- Chen Mao (ORCID: https://orcid.org/0000-0002-6537-6215)
- Xiaoyu Tian (ORCID: https://orcid.org/0000-0003-1384-8687)
- Xiaoyu Huang (ORCID: https://orcid.org/0000-0002-3672-1980)
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
- Guangdong Provincial People's Hospital (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1371/journal.pone.0335501
- Citations
- 1
- Primary Topic
- Cancer Mechanisms and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- National Natural Science Foundation of China