Alterations in renal Na,K-ATPase activity and protein expression in rat models of pressure and volume overload
With regard to functional properties of the Na, K-ATPase, an increased number of substrate molecules converted to products per active site per unit time (indicated by V<sub>max</sub>) was detected in the kidney of TGR(mREN2)27 rats. Although the creation of ACF did not alter the V<sub>max</sub> parameter, a notable impairment in the enzyme's ability to bind ATP substrate within physiologically relevant concentrations was observed in TGR(mREN2)27 rats, but not in HAN rats.
Authors
- Norbert Vrbjar (ORCID: https://orcid.org/0000-0002-1640-6641)
- Matúš Sýkora (ORCID: https://orcid.org/0000-0002-0438-3956)
- Katarína Andelová (ORCID: https://orcid.org/0000-0002-1499-7687)
- Jana Radošinská (ORCID: https://orcid.org/0000-0001-6703-5863)
- Denisa Snurikova (ORCID: https://orcid.org/0000-0002-9321-4002)
- Barbara Szeiffová Bačová (ORCID: https://orcid.org/0000-0001-8394-7459)
- Luděk Červenka (ORCID: https://orcid.org/0000-0002-2256-9631)
- Ivona Kovačičová
Institutions
- Slovak Academy of Sciences (SK)
- Institute of Experimental Endocrinology of the Slovak Academy of Sciences (SK)
- Institute of Clinical and Experimental Medicine (CZ)
- Centre of Experimental Medicine of the Slovak Academy of Sciences (SK)
- Comenius University Bratislava (SK)
Publication Details
- Journal
- Scientific Reports
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1038/s41598-025-23241-2
- Primary Topic
- Ion Transport and Channel Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00