Ampicillin/Sulbactam in Combination with Ceftazidime/Avibactam Against Metallo-β-Lactamase-Producing Carbapenem-Resistant <i>Acinetobacter baumannii</i> : A Genomics-Informed Mechanism-based model
This study highlights the potential of integrating genomic insights into MBM to optimize antibiotic regimens. The ampicillin/sulbactam and ceftazidime/avibactam combinations demonstrated promising activity against highly resistant CRAB strains, supporting their potential for clinical application in managing difficult-to-treat infections.
Authors
- Robert A. Bonomo (ORCID: https://orcid.org/0000-0002-3299-894X)
- Fernando Pasterán (ORCID: https://orcid.org/0000-0001-5840-5869)
- Quentin Vallé (ORCID: https://orcid.org/0000-0002-1525-9993)
- David L. Paterson (ORCID: https://orcid.org/0000-0003-2079-4437)
- Eloise Liu
- Germán M. Traglia (ORCID: https://orcid.org/0000-0002-4780-5311)
- María Soledad Ramirez
- Vyanka Mezcord (ORCID: https://orcid.org/0000-0003-1896-8450)
- Gauri G. Rao (ORCID: https://orcid.org/0000-0002-8704-7770)
- Rajnikant Sharma (ORCID: https://orcid.org/0000-0002-0891-7548)
- Bhavatharini Arun (ORCID: https://orcid.org/0000-0001-7784-0241)
- Irene Luu (ORCID: https://orcid.org/0009-0007-6890-3619)
- Ngoc Minh Bui (ORCID: https://orcid.org/0009-0001-5780-0864)
Institutions
- University of Southern California (US)
- California State University, Fullerton (US)
- National University of Singapore (SG)
- Universidad Nacional del Litoral (AR)
- Administración Nacional de Laboratorios e Institutos de Salud (AR)
- National University Health System (SG)
- University School (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1093/infdis/jiaf567
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health