Antibiotic Use and the Persistence of Biologic Therapies in Patients With Psoriasis
In this cohort study, antibiotic exposure was significantly associated with an increased risk of discontinuation of biologic therapies in psoriasis. These findings support the hypothesis that antibiotics, potentially through gut dysbiosis, may reduce biologic persistence. However, unmeasured confounders limit causal interpretation. Further studies are necessary to validate these findings.
Authors
- D. Jullien (ORCID: https://orcid.org/0000-0002-2995-7928)
- É. Sbidian (ORCID: https://orcid.org/0000-0002-1267-5270)
- Laëtitia Penso (ORCID: https://orcid.org/0000-0003-1562-0168)
- Harry Sokol (ORCID: https://orcid.org/0000-0002-2914-1822)
- Raphaël Ouakrat (ORCID: https://orcid.org/0009-0007-6954-7150)
Institutions
- Inserm (FR)
- Université Paris-Est Créteil (FR)
- Microbiologie de l’alimentation au service de la santé (FR)
- Centre Hospitalier Universitaire Henri-Mondor (FR)
- Sorbonne Université (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hospices Civils de Lyon (FR)
- Hôpital Saint-Antoine (FR)
- Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine (FR)
- Hôpital Edouard Herriot (FR)
- Hôpitaux Universitaires Henri-Mondor (FR)
- Centre de Recherche Saint-Antoine (FR)
Publication Details
- Journal
- JAMA Dermatology
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1001/jamadermatol.2025.4427
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00