Garlicinals A–D: Bioactive Organosulfur α,β-Unsaturated Aldehydes from Garlic ( <i>Allium sativum</i> L.) Hydrolate

Four sulfur-derived compounds, garlicinals A-D (<b>1-4</b>), were isolated from the garlic (<i>Allium sativum</i>) bulb hydrolate. The structural elucidation of <b>1-4</b> was achieved with the help of HRMS and 1D and 2D NMR. All of these compounds are characterized by an α,β-unsaturated aldehyde in their structure. Noteworthy, this structural motif is unique in garlic-derived compounds, which would convert them into a new family of garlic-derived organosulfur compounds. A synthetic path to these compounds is proposed. Garlicinals <b>A-C</b> showed potent fungicidal activity against plant pathogens (<i>Aspergillus niger</i> and <i>Botrytis cinerea</i>). Furthermore, <b>1-4</b> were active against the nematode <i>Meloidogyne javanica</i>.