Metabolite maps reveal spatial gradients in liver and intestinal tissue

The abundances and fluxes of metabolite molecules were measured at cellular resolution in the mouse liver and small intestine. The levels of most metabolites showed considerable gradients in both organs. Furthermore, intake of the sugar fructose triggered depletion of ATP molecules at foci in the liver. The sugar fructose disrupts the metabolic organization of the liver.

Publication Details

Journal
Nature
Published
2025-11-12
DOI
https://doi.org/10.1038/d41586-025-03457-y
Primary Topic
Cancer, Hypoxia, and Metabolism
Type
article
Field-Weighted Citation Impact
0.00
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article

Metabolite maps reveal spatial gradients in liver and intestinal tissue

Nature
Cancer, Hypoxia, and Metabolism
article

Metabolite maps reveal spatial gradients in liver and intestinal tissue

article en

Abstract

The abundances and fluxes of metabolite molecules were measured at cellular resolution in the mouse liver and small intestine. The levels of most metabolites showed considerable gradients in both organs. Furthermore, intake of the sugar fructose triggered depletion of ATP molecules at foci in the liver. The sugar fructose disrupts the metabolic organization of the liver.

Nature
Openalex Percentile: Top 58%
Cancer, Hypoxia, and Metabolism
DOIOpen Access PDFOpenAlex
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Metabolite maps reveal spatial gradients in liver and intestinal tissue · Nature (2025) | TGRS Research Map | TGRS