Unraveling the nexus between lung cancer and rheumatoid arthritis using integrative transcriptomics and genomics

This study delineates potential common mechanisms between LC and RA, suggesting that an enhanced viral response, attenuated TCR signaling, and reduced T cell activation in the peripheral system may represent shared pathological mechanisms, potentially contributing to the increased LC risk in RA patients. Conversely regulated DEGs may serve as novel biomarkers for pulmonary diseases. The changes in immune-related pathways and their potential association with lymphocyte activity provide new perspectives for understanding the relationship between LC and RA.