Proteome organ aging and cardiometabolic risk in a population at risk for heart failure
Proteome-derived organ aging correlates with HF severity, with possible sex-related patterns. Diabetes and higher TyG-BMI are associated with faster organ aging, which may reflect shared aging mechanisms between metabolic dysfunction and HF.
Authors
- Kaiyong Qu (ORCID: https://orcid.org/0000-0002-5295-0361)
- Elisa Dal Canto (ORCID: https://orcid.org/0000-0001-8999-9946)
- Igor I. Tulevski (ORCID: https://orcid.org/0000-0002-8507-1531)
- Sabrina Abou Kamar
- G. Aernout Somsen (ORCID: https://orcid.org/0000-0001-5690-4429)
- Frans Hendrik Rutten (ORCID: https://orcid.org/0000-0002-5052-7332)
- Leonard Hofstra (ORCID: https://orcid.org/0000-0003-4432-4720)
- Maarten J. Cramer (ORCID: https://orcid.org/0000-0002-6041-6759)
- Isabella Kardys (ORCID: https://orcid.org/0000-0002-2115-9745)
- Anne‐Mar L. N. van Ommen
- Ernest Diez Benavente (ORCID: https://orcid.org/0000-0002-4313-4290)
- Roxana Menken (ORCID: https://orcid.org/0000-0002-6314-9238)
- Marianne Christina Verhaar (ORCID: https://orcid.org/0000-0002-3276-6428)
- Dirk Jan Duncker (ORCID: https://orcid.org/0000-0003-2836-2241)
- Arco J. Teske (ORCID: https://orcid.org/0000-0001-5305-1619)
- Hester M. den Ruijter (ORCID: https://orcid.org/0000-0001-9762-014X)
- N. Charlotte Onland-Moret
Institutions
- Utrecht University (NL)
- Erasmus MC (NL)
- University Medical Center Utrecht (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1186/s12933-025-02980-6
- Citations
- 2
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 3.34
Funders
- Dutch Cardiovascular Alliance