Bif-1 induces vascular remodeling in injured rat carotid artery by engaging β-catenin signaling
Together, our findings suggest that Bif-1 is a novel vascular injury-response molecule that promotes VSMC proliferation, migration, and phenotypic switch. Thus, the inhibition of Bif-1-mediated activation of β-catenin signaling represents a promising therapeutic strategy for preventing VSMC accumulation and vascular obstructive diseases following injury.
Authors
- Jie Wei
- Xin Jiang (ORCID: https://orcid.org/0000-0001-6663-4063)
- Chaorui Wang
- Yun Liu
- Wei Han (ORCID: https://orcid.org/0000-0002-8578-6780)
- Jie Li (ORCID: https://orcid.org/0000-0002-6175-3167)
- Yi Xu
- Ning Hou (ORCID: https://orcid.org/0000-0002-7745-4946)
Institutions
- Longgang Central Hospital (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Pharmacy and Pharmacology
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1093/jpp/rgaf111
- Primary Topic
- Moyamoya disease diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00