Targeting NAD <sup>+</sup> Salvage Suppresses PBMC Inflammation to Improve Cognitive Function in Vascular Cognitive Impairment
Our findings suggest peripheral inflammation driven by impaired NAD<sup>+</sup> salvage and elevated eNAMPT levels in PBMCs plays a key role in VCI pathogenesis. Restoring NAD<sup>+</sup> homeostasis via 5'-phosphoribosyl-pyrophosphate treatment significantly improved cognition in VCI mice, highlighting NAD<sup>+</sup> salvage as a potential therapeutic target.
Authors
- Ze Li
- Rui Feng (ORCID: https://orcid.org/0000-0003-3895-8989)
- Wenxu Qi (ORCID: https://orcid.org/0000-0001-5605-5711)
- Yi-Ting Wang (ORCID: https://orcid.org/0009-0003-5204-5171)
- Hongyan Zhang (ORCID: https://orcid.org/0000-0001-8998-308X)
- Qiang Li (ORCID: https://orcid.org/0000-0003-3831-9001)
- Ke Zhang (ORCID: https://orcid.org/0009-0005-3248-8279)
Institutions
- Shenyang Pharmaceutical University (CN)
- Fourth Affiliated Hospital of China Medical University (CN)
- Ministry of Education (KR)
- China Medical University (CN)
Publication Details
- Journal
- Stroke
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1161/strokeaha.125.052431
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00