Development of a Semi-Mechanistic Population Pharmacokinetic Model for Predicting Tenofovir Disoproxil Fumarate and Tenofovir Alafenamide Exposure in Plasma and Cellular Matrices During Pregnancy and Postpartum
Our semi-mechanistic model provides a framework for understanding pregnancy-associated pharmacokinetic changes and supports future research to refine dosing strategies for HIV treatment and prevention in pregnancy.
Authors
- Craig W. Hendrix (ORCID: https://orcid.org/0000-0002-5696-8665)
- Peter L. Anderson (ORCID: https://orcid.org/0000-0002-1200-8494)
- Yifan Yu (ORCID: https://orcid.org/0009-0002-5291-9003)
- Renee A. Heffron (ORCID: https://orcid.org/0000-0001-6039-0352)
- Jeremiah D. Momper (ORCID: https://orcid.org/0000-0002-3154-6685)
- Kristina M. Brooks (ORCID: https://orcid.org/0000-0002-3832-8699)
- Robert R. Bies (ORCID: https://orcid.org/0000-0003-3818-2252)
- Rachel K. Scott (ORCID: https://orcid.org/0000-0002-1519-9222)
- Brookie M. Best (ORCID: https://orcid.org/0000-0001-8569-2293)
- Mark A. Marzinke (ORCID: https://orcid.org/0000-0003-1670-8786)
- Dvora Joseph Davey (ORCID: https://orcid.org/0000-0001-6290-9293)
- Landon Myer (ORCID: https://orcid.org/0000-0002-8106-7658)
- Jenell S. Coleman (ORCID: https://orcid.org/0000-0002-7546-7727)
- Connie Celum (ORCID: https://orcid.org/0000-0002-8813-3419)
- Mark Mirochnick
- Gustavo F. Doncel (ORCID: https://orcid.org/0009-0009-9641-1325)
Institutions
- Boston University (US)
- MedStar Washington Hospital Center (US)
- Johns Hopkins University (US)
- Eastern Virginia Medical School (US)
- University of Cape Town (ZA)
- University of California, Los Angeles (US)
- Georgetown University (US)
- University of Washington (US)
- Johns Hopkins Medicine (US)
- MedStar Georgetown University Hospital (US)
- University of Alabama at Birmingham (US)
- University of California San Diego (US)
- Rady Children's Hospital-San Diego (US)
- University of Colorado Anschutz Medical Campus (US)
- University at Buffalo, State University of New York (US)
- University of Montana (US)
- Old Dominion University (US)
- MedStar Health (US)
Publication Details
- Journal
- Clinical Pharmacokinetics
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1007/s40262-025-01589-y
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- United States Agency for International Development
- U.S. President’s Emergency Plan for AIDS Relief