Development of a Semi-Mechanistic Population Pharmacokinetic Model for Predicting Tenofovir Disoproxil Fumarate and Tenofovir Alafenamide Exposure in Plasma and Cellular Matrices During Pregnancy and Postpartum

Our semi-mechanistic model provides a framework for understanding pregnancy-associated pharmacokinetic changes and supports future research to refine dosing strategies for HIV treatment and prevention in pregnancy.

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Publication Details

Journal
Clinical Pharmacokinetics
Published
2025-11-12
DOI
https://doi.org/10.1007/s40262-025-01589-y
Primary Topic
HIV/AIDS drug development and treatment
Type
article
Field-Weighted Citation Impact
0.00

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article

Development of a Semi-Mechanistic Population Pharmacokinetic Model for Predicting Tenofovir Disoproxil Fumarate and Tenofovir Alafenamide Exposure in Plasma and Cellular Matrices During Pregnancy and Postpartum

Craig W. Hendrix, Peter L. Anderson, Yifan Yu, Renee A. Heffron et al.
Clinical Pharmacokinetics
HIV/AIDS drug development and treatment
article

Development of a Semi-Mechanistic Population Pharmacokinetic Model for Predicting Tenofovir Disoproxil Fumarate and Tenofovir Alafenamide Exposure in Plasma and Cellular Matrices During Pregnancy and Postpartum

Craig W. Hendrix, Peter L. Anderson, Yifan Yu, Renee A. Heffron, Jeremiah D. Momper, Kristina M. Brooks, Robert R. Bies, Rachel K. Scott, Brookie M. Best, Mark A. Marzinke, Dvora Joseph Davey, Landon Myer, Jenell S. Coleman, Connie Celum, Mark Mirochnick, Gustavo F. Doncel
article en

Abstract

Our semi-mechanistic model provides a framework for understanding pregnancy-associated pharmacokinetic changes and supports future research to refine dosing strategies for HIV treatment and prevention in pregnancy.

Clinical PharmacokineticsVol. 65(1)
Boston University (US), MedStar Washington Hospital Center (US), Johns Hopkins University (US), Eastern Virginia Medical School (US), University of Cape Town (ZA), University of California, Los Angeles (US), Georgetown University (US), University of Washington (US), Johns Hopkins Medicine (US), MedStar Georgetown University Hospital (US), University of Alabama at Birmingham (US), University of California San Diego (US), Rady Children's Hospital-San Diego (US), University of Colorado Anschutz Medical Campus (US), University at Buffalo, State University of New York (US), University of Montana (US), Old Dominion University (US), MedStar Health (US)
United States Agency for International Development, U.S. President’s Emergency Plan for AIDS Relief
Openalex Percentile: Top 60%
HIV/AIDS drug development and treatment
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