Disease Progression in Age-Related Macular Degeneration Patients Carrying Rare Variants in the Complement Factor H or Complement Factor I Genes
Carriers of rare CFI or CFH variants show a higher incidence of late AMD. These patients may benefit from personalized gene therapy and complement inhibition in future trials.
Authors
- Yara Lechanteur (ORCID: https://orcid.org/0000-0003-0951-4625)
- Bart Liefers (ORCID: https://orcid.org/0000-0002-2763-6426)
- Sarah de Jong (ORCID: https://orcid.org/0000-0002-3705-3371)
- Caroline C. W. Klaver (ORCID: https://orcid.org/0000-0002-2355-5258)
- Anita de Breuk (ORCID: https://orcid.org/0000-0001-7072-1928)
- Thomas J. Heesterbeek (ORCID: https://orcid.org/0000-0002-3232-2587)
- Eric F. Thee (ORCID: https://orcid.org/0000-0003-2493-1996)
- Jeroen Vermeulen (ORCID: https://orcid.org/0000-0001-7166-7759)
- Francesco Cinque (ORCID: https://orcid.org/0000-0003-4354-6241)
- Carel B. Hoyng (ORCID: https://orcid.org/0000-0002-1358-5963)
- Anneke I. den Hollander
- Anneke I. den Hollander
- Haras Mhmud
Institutions
- Radboud University Nijmegen (NL)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
- Institute of Molecular and Clinical Ophthalmology Basel (CH)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1167/iovs.66.14.23
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek