Choroidal Mast Cells and Their Degranulation Are a Pivotal Trigger for Myopia Development
Choroidal MC degranulation plays a critical role in LIM by promoting choroidal thinning and axial elongation. These findings enhance our understanding of the role of choroidal MC degranulation in myopia, suggesting a potential therapeutic target for myopia treatment.
Authors
- T. Fukuchi (ORCID: https://orcid.org/0000-0003-3566-9954)
- Satoshi Imanishi
- Junhan Chen (ORCID: https://orcid.org/0000-0001-8238-2222)
- S. Ikeda (ORCID: https://orcid.org/0000-0003-2134-7786)
- Junsheng Shi (ORCID: https://orcid.org/0000-0003-1897-8237)
- Toshihide Kurihara (ORCID: https://orcid.org/0000-0002-5457-2720)
- Kate Gettinger
- Kazuo Tsubota
- Kazuno Negishi
Institutions
- Keio University (JP)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1167/iovs.66.14.22
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Keio University
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science
- Japan Science and Technology Agency