Cefiderocol and Moxifloxacin Have Additive and Synergistic Activity Against <i>Pseudomonas aeruginosa</i> Including an Isolate of the 2023 Keratitis Outbreak
Cefiderocol and moxifloxacin exhibited synergy against most tested P. aeruginosa keratitis isolates in vitro, including those with suspected quorum-sensing defects. These findings support further investigation of this combination for treating highly drug-resistant ocular infections.
Authors
- Michael E. Zegans (ORCID: https://orcid.org/0000-0003-3074-7589)
- Robert M. Q. Shanks (ORCID: https://orcid.org/0000-0002-7699-5396)
- Eric G. Romanowski (ORCID: https://orcid.org/0000-0003-4246-3276)
- Emily Young
- Sonya M. Mumper (ORCID: https://orcid.org/0009-0003-1584-0811)
- Brennan M. Schilling
Institutions
- Dartmouth College (US)
- University of Pittsburgh (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1167/iovs.66.14.19
- Primary Topic
- Ocular Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00