Sustained remission with PD-1 and BTK inhibitors maintenance after chimeric antigen receptor T-cell therapy in CNS lymphoma
Our findings suggested the promising efficacy and manageable toxicities of CAR-T therapy in patients with CNSL. This study preliminarily proposed the concept that maintenance therapy may improve the DOR after CAR-T therapy.
Authors
- Danqing Kong (ORCID: https://orcid.org/0000-0002-0816-4523)
- Rui Zou (ORCID: https://orcid.org/0000-0002-0542-1264)
- Nana Ping
- Changju Qu (ORCID: https://orcid.org/0000-0003-1803-0008)
- Zhengming Jin (ORCID: https://orcid.org/0009-0000-1234-9646)
- Jiajie He (ORCID: https://orcid.org/0000-0002-1532-0870)
- Qian Zhu (ORCID: https://orcid.org/0000-0002-1203-3278)
- Junhong Li (ORCID: https://orcid.org/0000-0002-9878-9059)
- Lingzi Yu
- Fan Xia (ORCID: https://orcid.org/0000-0001-8185-8663)
- Junxuan Tu
- Depei Wu
- Xiao Zhang (ORCID: https://orcid.org/0009-0002-9537-8120)
Institutions
- Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1007/s00262-025-04236-4
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province