Combining molecular patterns and clinical data for better immune checkpoint inhibitor prediction in metastatic urothelial carcinoma
Our real-life cohort analysis confirms the limitations of standalone biomarkers like PD-L1. We identified gene expression-based markers with strong prognostic and predictive value for ICI treatment outcomes.
Authors
- Viktor Grünwald (ORCID: https://orcid.org/0000-0003-2083-7687)
- István Kenessey (ORCID: https://orcid.org/0000-0002-6963-8489)
- T. Szarvas
- Henning Reis (ORCID: https://orcid.org/0000-0003-1373-5295)
- Csilla Oláh (ORCID: https://orcid.org/0000-0002-4775-2432)
- Balázs Győrffy (ORCID: https://orcid.org/0000-0002-5772-3766)
- Michèle J. Hoffmann (ORCID: https://orcid.org/0000-0002-6044-1671)
- Bence Bátai (ORCID: https://orcid.org/0000-0002-5359-5314)
- G. Niegisch
- Martin Pošta (ORCID: https://orcid.org/0000-0001-9134-5204)
- Fabian Mairinger (ORCID: https://orcid.org/0000-0003-1067-0051)
- O. Horváth
- Ulrich Krafft (ORCID: https://orcid.org/0000-0002-0274-7445)
- Anita Csizmarik (ORCID: https://orcid.org/0000-0001-8394-3722)
- Anikó Maráz (ORCID: https://orcid.org/0000-0002-2018-8413)
- Florestan Koll (ORCID: https://orcid.org/0000-0001-7828-3950)
- Melinda Váradi (ORCID: https://orcid.org/0000-0001-7733-0831)
- Levente Kuthi (ORCID: https://orcid.org/0000-0001-9247-6679)
- Zoltán Herold (ORCID: https://orcid.org/0000-0001-5990-4889)
- C. L. Cotarelo
- B. Hadaschik
- Attila Marcell Szász (ORCID: https://orcid.org/0000-0003-2739-4196)
- Balázs Csaba Németh (ORCID: https://orcid.org/0000-0001-5338-7577)
- P. Nyirády
- Camilla M. Grunewald (ORCID: https://orcid.org/0000-0002-5069-3752)
- Michael Wessolly (ORCID: https://orcid.org/0000-0002-4399-8646)
- E Soós
Institutions
- Semmelweis University (HU)
- Goethe University Frankfurt (DE)
- Heidelberg University (DE)
- University of Szeged (HU)
- University Hospital Heidelberg (DE)
- Düsseldorf University Hospital (DE)
- Integrated Oncology (United States) (US)
- Essen University Hospital (DE)
- National Institute of Oncology (HU)
- University Medical Centre Mannheim (DE)
- Heinrich Heine University Düsseldorf (DE)
- University of Duisburg-Essen (DE)
- University of Pecs (HU)
- HUN-REN Research Centre for Natural Sciences (HU)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1007/s00262-025-04224-8
- Citations
- 4
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 8.03
Funders
- Semmelweis Egyetem
- Magyar Tudományos Akadémia
- Innovációs és Technológiai Minisztérium