Integrative analysis of single-cell and bulk transcriptome data reveals age-related immune cell alterations in primary glioblastoma associated with prognosis
Our study highlights the crucial role of microglial aging in pGBM, reveals distinct age-related changes of immune cells in the TME between pGBM and rGBM, and offers valuable insights into clinical treatment strategies targeting elderly GBM patients.
Authors
- Wei Han (ORCID: https://orcid.org/0000-0003-0033-1486)
- Bin Yin (ORCID: https://orcid.org/0000-0002-1762-7585)
- Bojun Qiu
- Chalganov Ai
- Zefan Jing
- Boyang Li (ORCID: https://orcid.org/0000-0003-2808-9986)
- Lin Hou (ORCID: https://orcid.org/0000-0003-2197-1394)
- Xinrun Wang (ORCID: https://orcid.org/0009-0000-6761-0506)
- Chunhui Wang (ORCID: https://orcid.org/0009-0009-7178-5742)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Institute of Laboratory Animal Science (CN)
- Peng Cheng Laboratory (CN)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1007/s00262-025-04206-w
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China