Dihydroagarofuran sesquiterpene derivatives from the roots of <i>Tripterygium wilfordii</i>
Two new (<b>1-2</b>) and five known (<b>3-7</b>) dihydro-<i>β</i>-agarofuran derivatives were isolated from the roots of <i>Tripterygium wilfordii</i>. The structures of new compounds were elucidated by spectroscopic techniques, such as UV, IR, HRESIMS and NMR. And the structure of compound <b>1</b> was confirmed by X-ray crystallographic. Cytotoxic activity assays against four human tumor cell lines (SK-MEL-2, HCC1806, HUH-7, PANC-1) were assessed for compounds <b>1-7</b>. Compound <b>2</b> exhibited pronounced cytotoxicity against SK-MEL-2 cells with an IC<sub>50</sub> value of 9.18 μM. Additionally, compound <b>5</b> showed significant cytotoxic effects on SK-MEL-2 and HCC1806 cells with IC<sub>50</sub> values of 4.59 μM and 8.14 μM, respectively.
Authors
- Ping-Ting Hong
- Chong Wang (ORCID: https://orcid.org/0000-0001-9486-7745)
- Ya-Lin Hu (ORCID: https://orcid.org/0009-0004-5990-9806)
- Yuting Lei (ORCID: https://orcid.org/0000-0001-9174-1389)
- Jiali Huang (ORCID: https://orcid.org/0000-0001-7514-4365)
- Wen Li (ORCID: https://orcid.org/0000-0002-8805-2934)
- Zhijie Li (ORCID: https://orcid.org/0000-0001-9870-9939)
- Wen‐Jie Chen (ORCID: https://orcid.org/0000-0002-9428-7828)
- Zhen Li (ORCID: https://orcid.org/0009-0006-4384-6358)
Institutions
- Hunan University of Traditional Chinese Medicine (CN)
- Hunan University of Science and Engineering (CN)
- Zhejiang Hisun Pharmaceutical (China) (CN)
Publication Details
- Journal
- Journal of Asian Natural Products Research
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1080/10286020.2025.2579867
- Primary Topic
- Natural Compounds in Disease Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00