Ketone ester supplementation protects from experimental colitis via improved goblet cell differentiation and function
The present study suggests that KE represent an effective anti-inflammatory dietary supplement in the context of acute colitis, potentially by modulating mucin2 expression, goblet cell differentiation, and the abundance of Akkermansia. Although promising, these findings remain preliminary, and further investigations are needed to explore the therapeutic potential of KE as a dietary supplement in patients with inflammatory bowel disease.
Authors
- Anika Sander (ORCID: https://orcid.org/0000-0001-8291-5607)
- Michelle Wiebel
- Anja A. Kühl (ORCID: https://orcid.org/0000-0003-2293-5387)
- Nadine Rohwer (ORCID: https://orcid.org/0000-0001-6170-1327)
- Soeren Ocvirk (ORCID: https://orcid.org/0000-0001-6547-2445)
- Nils Helge Schebb (ORCID: https://orcid.org/0000-0003-1299-6629)
- Tilman Grune (ORCID: https://orcid.org/0000-0003-4775-9973)
- Karsten H. Weylandt (ORCID: https://orcid.org/0000-0002-5361-4327)
Institutions
- University of Wuppertal (DE)
- University of Potsdam (DE)
- Humboldt-Universität zu Berlin (DE)
- Medizinische Hochschule Brandenburg Theodor Fontane (DE)
- Deutsches Diabetes-Zentrum e.V. (DE)
- Universitätsklinikum Brandenburg an der Havel (DE)
- German Center for Diabetes Research (DE)
- German Institute of Human Nutrition (DE)
- Heinrich Heine University Düsseldorf (DE)
- Brandenburg University of Technology Cottbus-Senftenberg (DE)
- Technical University of Munich (DE)
Publication Details
- Journal
- European Journal of Nutrition
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1007/s00394-025-03833-4
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft