Effectiveness of ketamine/esketamine in alleviating postoperative fatigue: a systematic review
Current evidence suggests that ketamine/esketamine may be effective in alleviating POF, particularly in major abdominal surgeries. These findings should be interpreted cautiously due to the heterogeneity in study designs, variations in fatigue assessment tools and time, and the limited sample sizes of the included studies. Future high-quality RCTs are needed to confirm these observations and establish the optimal dosing regimens.
Authors
- Yatao Liu
- Bo Yang (ORCID: https://orcid.org/0000-0002-1347-3718)
- Jingyi Xie (ORCID: https://orcid.org/0000-0002-2753-2360)
- Qijing Liu (ORCID: https://orcid.org/0000-0001-7353-0721)
- Jiayi Xie (ORCID: https://orcid.org/0000-0003-0930-9656)
- Ying Liu (ORCID: https://orcid.org/0000-0003-4445-1762)
- Chengying Ji (ORCID: https://orcid.org/0000-0002-3753-9785)
- Qian Fu
- Boxiong Gao (ORCID: https://orcid.org/0000-0002-3575-6292)
- Abdulrahman Khaled Alwesabi
Institutions
- First Hospital of Lanzhou University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- International Journal of Clinical Pharmacy
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1007/s11096-025-02052-5
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 0.00