PARP Inhibitors in Metastatic Castration-resistant Prostate Cancer: Rationale, Mechanisms, and Clinical Applications
Promising results have led to the approval of several PARPi agents as monotherapy or in combination with ARPIs in selected or unselected patients when chemotherapy is not clinically indicated. However, some questions remain regarding patient selection and treatment sequencing.
Authors
- Claire Jamet
- Denis Maillet (ORCID: https://orcid.org/0000-0001-6883-2696)
- Charlotte Joly (ORCID: https://orcid.org/0000-0003-2534-1867)
- Luca Campedel (ORCID: https://orcid.org/0000-0002-0046-0969)
- Marc‐Olivier Timsit (ORCID: https://orcid.org/0000-0002-5605-2956)
- Camille Serrate (ORCID: https://orcid.org/0000-0002-1383-5432)
- Aurélien Gobert
- Stéphane Oudard (ORCID: https://orcid.org/0000-0003-0893-285X)
- Émeline Colomba (ORCID: https://orcid.org/0000-0002-3631-316X)
- Guillaume Mouillet (ORCID: https://orcid.org/0000-0002-2288-7461)
- Guillaume Ploussard (ORCID: https://orcid.org/0000-0003-3799-4988)
- Louis Marie Dourthe
- Jean-Christophe Eymard
Institutions
- Université Paris Cité (FR)
- Université Paris-Saclay (FR)
- Institut Gustave Roussy (FR)
- Centre Hospitalier Universitaire Henri-Mondor (FR)
- Centre Hospitalier Universitaire de Besançon (FR)
- Hospices Civils de Lyon (FR)
- Hôpital Européen Georges-Pompidou (FR)
- Hôpital Européen (FR)
- Groupe Hospitalier Diaconesses Croix Saint-Simon (FR)
- Centre Hospitalier privé Saint Grégoire (FR)
- Metabolism and Renal Physiology (FR)
- Institut Claudius Regaud (FR)
- Hôpitaux Universitaires Henri-Mondor (FR)
- Centre Hospitalier de La Rochelle (FR)
- Clinique Ambroise Paré (FR)
- Institut Jean Godinot (FR)
- Centre Hospitalier Universitaire de Saint-Étienne (FR)
Publication Details
- Journal
- European Urology Oncology
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1016/j.euo.2025.10.011
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00